Smart Indoor Positioning/Location and Navigation: A Lightweight Approach

In this paper a new location indoor system is presented, which shows the position and orientation of the user in closed environments, as well as the optimal route to his destination through location tags. This system is called Labelee, and it makes easier the interaction between users and devices through QR code scanning or by NFC tag reading, because this technology is increasingly common in the latest smartphones. With this system, users could locate themselves into an enclosure with less interaction

Exercise Ventilatory Inefficiency in Post-COVID-19 Syndrome: Insights from a Prospective Evaluation

The present study was partially granted by Gerencia Regional de Salud de Castilla y León under grant number GRS COVID 111/A/20 and a grant from the Spanish Society of Cardiology SEC/FEC-INVCLI 2.Introduction: Coronavirus disease 2019 (COVID-19) is a systemic disease characterized by a disproportionate inflammatory response in the acute phase. This study sought to identify clinical sequelae and their potential mechanism. Methods: We conducted a prospective single-center study (NCT04689490) of previously hospitalized COVID-19 patients with and without dyspnea during mid-term follow-up. An outpatient group was also evaluated. They underwent serial testing with a cardiopulmonary exercise test (CPET), transthoracic echocardiogram, pulmonary lung test, six-minute walking test, serum biomarker analysis, and quality of life questionaries. Results: Patients with dyspnea (n = 41, 58.6%), compared with asymptomatic patients (n = 29, 41.4%), had a higher proportion of females (73.2 vs. 51.7%; p = 0.065) with comparable age and prevalence of cardiovascular risk factors. There were no significant differences in the transthoracic echocardiogram and pulmonary function test. Patients who complained of persistent dyspnea had a significant decline in predicted peak VO2 consumption (77.8 (64–92.5) vs. 99 (88–105); p 50% of COVID-19 survivors present a symptomatic functional impairment irrespective of age or prior hospitalization. Our findings suggest a potential ventilation/perfusion mismatch or hyperventilation syndrome.Fac. de MedicinaTRUEJunta de Castilla y León. Gerencia Regional de Salud de Castilla y LeónSociedad Española de Cardiologíapu

Management of acute diverticulitis with pericolic free gas (ADIFAS). an international multicenter observational study

Background: There are no specific recommendations regarding the optimal management of this group of patients. The World Society of Emergency Surgery suggested a nonoperative strategy with antibiotic therapy, but this was a weak recommendation. This study aims to identify the optimal management of patients with acute diverticulitis (AD) presenting with pericolic free air with or without pericolic fluid. Methods: A multicenter, prospective, international study of patients diagnosed with AD and pericolic-free air with or without pericolic free fluid at a computed tomography (CT) scan between May 2020 and June 2021 was included. Patients were excluded if they had intra-abdominal distant free air, an abscess, generalized peritonitis, or less than a 1-year follow-up. The primary outcome was the rate of failure of nonoperative management within the index admission. Secondary outcomes included the rate of failure of nonoperative management within the first year and risk factors for failure. Results: A total of 810 patients were recruited across 69 European and South American centers; 744 patients (92%) were treated nonoperatively, and 66 (8%) underwent immediate surgery. Baseline characteristics were similar between groups. Hinchey II-IV on diagnostic imaging was the only independent risk factor for surgical intervention during index admission (odds ratios: 12.5, 95% CI: 2.4-64, P =0.003). Among patients treated nonoperatively, at index admission, 697 (94%) patients were discharged without any complications, 35 (4.7%) required emergency surgery, and 12 (1.6%) percutaneous drainage. Free pericolic fluid on CT scan was associated with a higher risk of failure of nonoperative management (odds ratios: 4.9, 95% CI: 1.2-19.9, P =0.023), with 88% of success compared to 96% without free fluid ( P <0.001). The rate of treatment failure with nonoperative management during the first year of follow-up was 16.5%. Conclusion: Patients with AD presenting with pericolic free gas can be successfully managed nonoperatively in the vast majority of cases. Patients with both free pericolic gas and free pericolic fluid on a CT scan are at a higher risk of failing nonoperative management and require closer observation

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Report: Labour and social security law in Spain in 2013

El informe ha sido elaborado por la Sección Juvenil de la Asociación Española de Derecho del Trabajo y Seguridad SocialEste documento intenta reflejar algunos de los principales cambios y novedades del ordenamiento laboral español en 2013, levantando acta de cómo la mutabilidad de nuestro Derecho del Trabajo es imparable. Este informe, consciente de ello, ofrece una selección de elementos esenciales, a juicio de sus autores, especialistas en cada una de las materias, encuadrados en la Sección Juvenil de la Asociación Española de Derecho del Trabajo y de la Seguridad Social. En él, conforme a la organización de dicha Sección en grupos de trabajo, se abordan las novedades más relevantes en materia de derechos fundamentales inespecíficos, contratación laboral, vicisitudes del contrato de trabajo, Derecho colectivo, conciliación y corresponsabilidad, protección social y prevención de riesgos laborales.This paper tries to show some of the many changes and novelties in Spanish Labour Law during 2013, drawing up a record of the unstoppable character of our Labour legal system. This report offers a selection of essential elements, according to its authors, all of them specialists in each one of the subjects, being part of the Young Scholars’ Section of the Spanish Association for Labour and Social Security Law. According to the organization of the said Section in working groups, we can find novelties concerning unspecific fundamental rights, work contracts, the life of the work contract and collective Labour Law, reconciliation and co responsibility, social protection and occupational risk preventio

Creación de un framework metodológico para las Technical Due Diligences

A Due Diligence generally covers the financial, accounting, commercial and technological fields. In the first three, it is easier to be able to do a complete analysis, because you work with objective data such as balance sheets, economic results, indebtedness, etc. However, the technological part is much more complicated to evaluate since there is no specific methodology that provides measurable and objective data that will help us to provide information in decision-making. The complexity inherent in investing in start-ups is since a large part of the company is intangible and difficult to measure; How do I evaluate the technological ecosystem, the development methodology or the adoption of the product? At present, this type of report is carried out arbitrarily, and sometimes it only consists of interviews with the development team about the code and the operation of the application or the technological part is ignored and only the financial and marketing part is evaluated. which represents a clear risk, as it does not have all the necessary information and relevant data that facilitate decisionmaking in a more accurate way. Thus, it is about establishing an intuitive and safe methodology that can cover in a precise and standardized way all the aspects to be evaluated in a Technical Due Diligence and the necessary tools for its implementation. To this end, six control areas have been defined, covering all aspects and technical and operational particularities of start-ups. These areas of control are the team, the technology ecosystem, technology competency, product adoption and maturity, development processes, and product technology. To achieve these six areas of control, the existing literature has been reviewed and analysed, and a survey of 30 leading experts was carried out, asking them about the highlights to consider when evaluating a start-up, and finally, different existing Due Diligence methods were reviewed. Once the areas have been identified, control and evaluation points have been established because of the investigation, which has provided a measurable and qualifiable model. This model has evolved into a prototype that has approximately 100 questions to collect information, and through a mathematical calculation provides specific data on the risk and value of the company, as well as recommendations and aspects to improve. To evaluate the methodology, historical data from 43 start-ups has been used, whose indicators and data have served to feed, compare, and extract the results and conclude that both the result of the evaluation and the recommendations provided are valid and help and facilitate decision making when valuing an asset. Also, a validation has been carried out after entering the known data of 15 start-ups in the prototype, answering all the questions in the questionnaire and checking that the result obtained is aligned with the evolution of start-ups in recent years. In addition, applying the proposed methodology, each of the six areas can be analysed and thus identify where there is more room for improvement to carry out the necessary corrective actions and be able to increase the value of the asset.Una Due Diligence generalmente cubre el ámbito financiero, contable, comercial y tecnológico. En las tres primeras, resulta más sencillo ser capaz de hacer un análisis completo, debido a que se trabaja con datos objetivos como balances, resultados económicos, endeudamiento, etc. Sin embargo, la parte tecnológica resulta mucho más complicada de evaluar ya que no existe una metodología específica que proporcione datos medibles y objetivos que nos sirvan para aportar información en la toma de decisiones. La complejidad inherente a la inversión en start-ups se debe a que una gran parte de la empresa es intangible y difícil de medir; ¿cómo evalúo el ecosistema tecnológico, la metodología de desarrollo o la adopción del producto? En la actualidad este tipo de informes se realiza de forma arbitraria, y en ocasiones solo consta de entrevistas al equipo de desarrollo sobre el código y el funcionamiento de la aplicación o se ignora la parte tecnológica y únicamente se evalúa la parte financiera y de marketing, lo cual representa un claro riesgo, al no disponer de toda la información necesaria y los datos relevantes que faciliten la toma de decisiones de forma más acertada. Así pues, se trata de establecer una metodología intuitiva y segura que sea capaz de cubrir de una forma precisa y estandarizada todos los aspectos a evaluar en una Technical Due Diligence y las herramientas necesarias para su implementación. Para ello se han definido seis áreas de control, cubriendo todos los aspectos y particularidades técnicas y operativas de las start-ups. Estas áreas de control son el equipo, el ecosistema tecnológico, la competencia tecnológica, la adopción y madurez del producto, los procesos de desarrollo y la tecnología de producto. Para conseguir como resultado estas seis áreas de control, se ha revisado y analizado la literatura existente, además se llevó a cabo una encuesta a 30 expertos destacados en donde se les preguntó sobre los aspectos destacados a tener en cuenta a la hora de evaluar una start-up y por último se revisaron diferentes métodos existentes de Due Diligences. Una vez identificadas las áreas, se han establecido unos puntos de control y evaluación como resultado de la investigación, lo que ha proporcionado un modelo medible y calificable. Este modelo ha evolucionado a un prototipo que cuenta con aproximadamente 100 preguntas para la toma de información, y mediante un cálculo matemático proporciona datos concretos sobre el riesgo y valor de la empresa, además de recomendaciones y aspectos a mejorar. Para evaluar la metodología, se ha contado con datos históricos de 43 start-ups, cuyos indicadores y datos han servido para alimentar, comparar y extraer los resultados y concluir que tanto el resultado de la evaluación como las recomendaciones proporcionadas son válidas y ayudan y facilitan la toma de decisiones a la hora de valorar un activo. Además, se ha llevado a cabo una validación después de introducir los datos conocidos de 15 start-ups en el prototipo, respondiendo a todas las preguntas del cuestionario y revisando que el resultado obtenido está alineado con la evolución de las start-ups en los últimos años. Aplicando la metodología propuesta, se puede analizar cada una de las seis áreas y así identificar dónde hay más espacio de mejora para llevar a cabo las acciones correctivas necesarias y poder incrementar el valor del activo

Application of Automobile Modelling Optimization Design Based on Virtual Reality Technology

Automobile architecture is a crucial phase in the process of design. The model assessment process in the hybrid vehicle modeling assessment becomes more in-depth, and designers exchange ideas. The critical aspect of automotive modeling is that various models have varying views on vehicle styling. The evaluation process is long, complicated, and efficient in automotive simulation. The evaluation process takes time. Therefore, in the paper, an Automobile Modelling Optimization Design Based on Virtual Reality Technology (AMOD-VRT) is proposed to improve automobile modeling and design research to be more interactive. Computational Design Method is used to create and design the entire vehicle as well as its surrounding environment. An Integrated Virtual Analysis can enclose the models mentioned above and create a virtual environment in which the user can interact to design a model virtually by themselves. The paper provides complete virtual design modeling of an automobile, allowing the user to work more efficiently based on the results. By applying virtual reality technology in the automobile design phase, interactive and network-based remote research on automobile modeling can make the automobile design progression more appropriate, easier to communicate with designers and decrease automobile design's development cost and cycle. The simulation analysis is performed based on safety, performance, and efficiency, proving the reliability of the proposed framework. Various parameters obtain the simulation results on automobile design as the automobile vehicle design performance ratio is 87.16%, increasing the visual effects in AMOD ratio is 88.77%, improving visual effects with optimized design ratio is 84.5%, interaction and collaboration of automobile modeling ratio are 82.26% and reduce vehicles accident using virtual reality ratio is 93.80%. The computer-based virtual reality technology in the automotive industry can effectively accelerate new product development in the future

Deep learning approach to Automated data collection and processing of video surveillance in sports activity prediction

Human activity recognition is one of today's key fields of automated video surveillance. The technology of smart surveillance technology plays a crucial role. Despite efforts in recent years, it is still difficult to recognize human behaviors from live video. Human activity can vary from basic behaviors to complicated behaviors. Depth cameras currently released have an efficient 3D estimate of body connecting locations in the temporal depth map collection. This article proposed a method for recognizing human behavior and considered the challenge of achieving a descriptive marking of activities by labeling individual sub-activities. The behaviors take place over a long period and have many sequential sub-activities. A sports activity prediction of video surveillance framework is proposed in this article. The suggested operation descriptor considers the sequence classification challenge to be the behavior recognition problem. Deep Learning is used to detect human behaviors in the proposed method. The method is tested on two regular identification benchmark functions. Effects of the research revealed that the solution developed exceeds cutting-edge methodologies

Smart indoor positioning/location and navigation: a lightweight approach

In this paper a new location indoor system is presented, which shows the position and orientation of the user in closed environments, as well as the optimal route to his destination through location tags. This system is called Labelee, and it makes easier the interaction between users and devices through QR code scanning or by NFC tag reading, because this technology is increasingly common in the latest smartphones. With this system, users could locate themselves into an enclosure with less interaction